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Veterinary Pathology, Vol 16, Issue 4 405-412, Copyright © 1979 by American College of Veterinary Pathologists

ARTICLES

A lymphomatoid granulomatosis of the lungs in young dogs

V. M. Lucke, D. F. Kelly, G. A. Harrington, C. Gibbs and C. J. Gaskell

Clinical signs in three young dogs with primary lung neoplasms included cough, weight loss and anorexia. Chest radiographs taken in the terminal stages of the disease showed nodular and diffuse consolidation of the lungs typical of primary neoplasms. Macroscopically the lungs were infiltrated by firm, pale tissue; similar tissue replaced the enlarged bronchial lymph nodes. In two dogs similar deposits were found also in the liver and spleen. The infiltrates were composed of atypical, polymorphous lymphoreticular cells. Invasion of pulmonary blood vessels and of bronchi and bronchioles was striking. The lesions closely resembled those of lymphomatoid granulomatosis, a rare human disease of unknown cause.


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H.-M Park, D.-N Hwang, B.-T Kang, D.-I Jung, G.-S Song, S.-J Lee, J.-Y Yhee, C.-H Yu, A. R. Doster, and J.-H Sur
Pulmonary Lymphomatoid Granulomatosis in a Dog: Evidence of Immunophenotypic Diversity and Relationship to Human Pulmonary Lymphomatoid Granulomatosis and Pulmonary Hodgkin's Disease
Vet. Pathol., November 1, 2007; 44(6): 921 - 923.
[Abstract] [Full Text] [PDF]


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