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Veterinary Pathology, Vol 16, Issue 5 530-538, Copyright © 1979 by American College of Veterinary Pathologists

ARTICLES

Niemann-Pick disease in a poodle dog

A. Bundza, J. A. Lowden and K. M. Charlton

A 5-month-old minature Poodle dog had widespread cytoplasmic vacuolation of neurons in the central nervous system and foamy macrophages in the lung, spleen, renal lymph node, liver, adrenal gland and intestine. Concentric membranous cytoplasmic inclusions were seen in the neurons of the central nervous system by electron microscopy. There was no sphingomyelinase in the brain tissue. Sphingomyelin and cholesterol were increased in brain, kidney and liver. A diagnosis of Niemann-Pick Disease was based on absence of sphingomyelinase activity, as well as on histologic, histochemical and chemical findings.


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D. Wenger, M Sattler, T Kudoh, S. Snyder, and R. Kingston
Niemann-Pick disease: a genetic model in Siamese cats
Science, June 27, 1980; 208(4451): 1471 - 1473.
[Abstract] [PDF]


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Copyright © 1979 by the American College of Veterinary Pathologists.