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Veterinary Pathology, Vol 16, Issue 6 693-701, Copyright © 1979 by American College of Veterinary Pathologists

ARTICLES

Ultrastructure of canine urinary bladder carcinoma

J. Alroy

Luminal and intraepithelial asymmetric unit membrane plaques were found in the urinary bladder urothelium of normal dogs. Tight junctions were found only at the apical poles of the luminal cells. In four dogs with spontaneous urinary bladder carcinomas the asymmetric unit membrane plaques were replaced by symmetric unit membrane. In the neoplastic luminal cells the tight junctions were partially attenuated. Invasive and metastatic neoplastic cells had some tight junction at the stromal interface. Some gap junctions were seen in the normal urothelium but not in the neoplastic cells. The amount of desmosomes in the neoplastic cells varied according to their direction of differentiation (transitional, squamous or glandular).


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A. B. Singh and R. C. Harris
Epidermal Growth Factor Receptor Activation Differentially Regulates Claudin Expression and Enhances Transepithelial Resistance in Madin-Darby Canine Kidney Cells
J. Biol. Chem., January 30, 2004; 279(5): 3543 - 3552.
[Abstract] [Full Text] [PDF]


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