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Veterinary Pathology, Vol 17, Issue 4 469-476, Copyright © 1980 by American College of Veterinary Pathologists

ARTICLES

Reversible dermal atrophy in a cat treated with phenytoin

S. W. Barthold, B. J. Kaplan and A. Schwartz

Phenytoin, given to a cat in proportions therapeutic for man (5 to 8 mg/kg), induced severe dermal atrophy with excessive fragility of the skin following daily oral administration for 3 weeks. Dermal collagen was depleted, but remaining collagen seemed structurally normal. Upon cessation of phenytoin treatment, the cat recovered. In an effort to establish an association between phenytoin treatment and a dermal collagen disorder, phenytoin treatment was repeated and the dermal lesion confirmed.




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Copyright © 1980 by the American College of Veterinary Pathologists.