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Veterinary Pathology, Vol 22, Issue 4 409-414, Copyright © 1985 by American College of Veterinary Pathologists

ARTICLES

Enhanced myotoxicity and involvement of both type I and II fibers in monensin-tiamulin toxicosis in pigs

T. Umemura, A. Kawaminami, M. Goryo and C. Itakura

Simultaneous administration of monensin and tiamulin to pigs resulted in enhanced myotoxicity. Skeletal muscles of tongue, diaphragm and legs were preferentially affected, whereas the masseter, longissimus thoracis and cardiac muscles, including the left auricle, were spared. Histochemical examination revealed an involvement of both type I and II fibers of skeletal muscles.


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 Drug Metab. Dispos.Home page
C. Nebbia, L. Ceppa, M. Dacasto, M. Carletti, and C. Nachtmann
Oxidative Metabolism of Monensin in Rat Liver Microsomes and Interactions with Tiamulin and Other Chemotherapeutic Agents: Evidence for the Involvement of Cytochrome P-450 3A Subfamily
Drug Metab. Dispos., September 1, 1999; 27(9): 1039 - 1044.
[Abstract] [Full Text]


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