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Veterinary Pathology, Vol 22, Issue 6 552-560, Copyright © 1985 by American College of Veterinary Pathologists

ARTICLES

An ultrastructural study of adenocarcinoma of the small intestine in sheep

A. D. Ross and W. A. Day

The ultrastructural appearance at primary and metastatic sites of ten ovine small intestinal adenocarcinomas was that of scirrhous tubular adenocarcinoma. Polygonal undifferentiated tumor cells had desmosomes, folded nuclei, and moderate numbers of mitochondria but few other organelles. More differentiated cells were columnar with apical microvilli and basal nuclei. They contained granular endoplasmic reticulum, Golgi and secretory granules. Microvillus-lined intracytoplasmic lumina (5-10 micron diameter), fibrous filaments (10 nm diameter, up to 1.4 micron length) and tubular paracrystalline arrays (hexagonal symmetry, 37-nm periodicity) in lumina and secretory granules were seen in some tumor cells in all ten sheep.




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Copyright © 1985 by the American College of Veterinary Pathologists.