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Veterinary Pathology, Vol 23, Issue 1 16-20, Copyright © 1986 by American College of Veterinary Pathologists

ARTICLES

Feline leukemia virus-induced thrombocytopenia and macrothrombocytosis in cats

J. T. Boyce, G. J. Kociba, R. M. Jacobs and M. G. Weiser

The Kawakami-Theilen strain of feline leukemia virus (FeLV-KT), an exogenous anemia-inducing retrovirus, induced significant macrothrombocytosis and thrombocytopenia during acute infections of cats. The geometric mean platelet volumes of both freshly isolated fixed platelets and ethylenediamine tetraacetic acid-sphered platelets from infected cats were increased, but the ratio of fresh-fixed to ethylenediamine tetraacetic acid-sphered platelet volumes, an estimate of ethylenediamine tetraacetic acid-induced isovolumetric shape change, was normal. Total plasma membrane increased as the platelet volumes increased in FeLV-KT-infected cats, but estimated surface connected canalicular system surface area did not. Platelet concentrations were decreased 2 to 6 weeks after inoculation, but marked macrothrombocytosis resulted in a trend toward increased platelet mass on weeks 5 and 6 after inoculation. Thus, FeLV-KT-induced macrothrombocytosis may serve as a model of impaired platelet volume regulation. The platelet volume and platelet membrane surface area abnormalities found suggest that this model would allow studies of the megakaryocyte/platelet axis, particularly in the area of membrane formation and territorial demarcation.


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K. P. Carmichael, D. Bienzle, and J. J. McDonnell
Feline Leukemia Virus-associated Myelopathy in Cats
Vet. Pathol., September 1, 2002; 39(5): 536 - 545.
[Abstract] [Full Text] [PDF]


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