Vet Pathol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilcock, B. P.
Right arrow Articles by Peiffer, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilcock, B. P.
Right arrow Articles by Peiffer, R. L., Jr

Veterinary Pathology, Vol 23, Issue 4 418-424, Copyright © 1986 by American College of Veterinary Pathologists

ARTICLES

Morphology and behavior of primary ocular melanomas in 91 dogs

B. P. Wilcock and R. L. Peiffer Jr

Primary ocular melanocytic neoplasms from 91 dogs were divided into two groups by histologic criteria. Seventy-five were benign and composed of spindle-shaped and large polyhedral melanocytes similar to those of human ocular melanocytomas. Fifty-nine of these originated in the uvea where most resulted in uveitis, glaucoma, or hyphema prior to enucleation. None metastasized. Nineteen melanocytomas were limbal tumors. None metastasized, but three of nine incompletely excised tumors were found within the anterior chamber 2 to 3 years after the initial removal. Sixteen uveal melanocytic neoplasms were histologically malignant. Three had confirmed metastases, all within 3 months of enucleation. Cell type or pattern of growth within the globe were not predictive of biologic behavior. Our data suggest that the mitotic index is the best criterion for histologic identification of ocular melanomas with high metastatic potential. We propose that the classification of primary ocular melanomas be simplified to include only two categories: melanocytoma (benign) and melanoma (potentially malignant). Further behavioral data may justify a grading scheme for melanomas based upon mitotic index.


This article has been cited by other articles:


Home page
 IOVSHome page
R. Folberg, S. S. Kadkol, S. Frenkel, K. Valyi-Nagy, M. J. Jager, J. Pe'er, and A. J. Maniotis
Authenticating Cell Lines in Ophthalmic Research Laboratories
Invest. Ophthalmol. Vis. Sci., November 1, 2008; 49(11): 4697 - 4701.
[Full Text] [PDF]

Home page
 Vet PatholHome page
Y. Shimoyama, Y. Akihara, D. Kirat, H. Iwano, K. Hirayama, Y. Kagawa, T. Ohmachi, K. Matsuda, M. Okamoto, T. Kadosawa, et al.
Expression of Monocarboxylate Transporter 1 in Oral and Ocular Canine Melanocytic Tumors
Vet. Pathol., July 1, 2007; 44(4): 449 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
S. H. Smith, M. H. Goldschmidt, and P. M. McManus
A Comparative Review of Melanocytic Neoplasms
Vet. Pathol., November 1, 2002; 39(6): 651 - 678.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American College of Veterinary Pathologists.