Veterinary Pathology, Vol 25, Issue 6 492-502, Copyright © 1988 by American College of Veterinary Pathologists

ARTICLES

Cardiovascular complications of chronic catheterization of the jugular vein in the dog

G. M. Mesfin, M. J. Higgins, W. P. Brown and D. Rosnick
Pathology and Toxicology Research, Upjohn Company, Kalamazoo, MI.

Cardiovascular changes associated with indwelling catheters were evaluated in 51 adult beagle dogs catheterized for 4 to 9 weeks. Pathologic changes consistent with traumatic injury were in the vena cava and endocardium of the right atrium of 88% of cannulated dogs. Lesions were characterized by surface denudation and diffuse intimal thickening due to myointimal hyperplasia and deposition of extracellular matrix. Affected intima was lined by hyperplastic, poorly differentiated endothelial cells and contained round to oval cells with characteristics of smooth muscle cells. After 9 weeks, thickened intima was vascularized and composed of spindle-shaped cells and fibrillar stroma. Intimal sclerosis and localized proliferative papillary projections in the vena cava cranial to areas of myointimal hyperplasia occurred infrequently. Traumatic lesions, regardless of location or severity, did not extend below the internal elastic membrane. Inflammatory cellular responses, when present, were minimal. The location, distribution, and morphogenesis of catheter-related cardiovascular lesions distinguishes them from those induced by chemical toxicity or pharmacotoxicity.
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				J. Lilbert and V. Mowat Common Vascular Changes in the Jugular Vein of Saline Controls in Continuous Infusion Studies in the Beagle Dog Toxicol Pathol, October 1, 2004; 32(6): 694 - 700. [Abstract] [PDF]