Veterinary Pathology, Vol 30, Issue 2 195-203, Copyright © 1993 by American College of Veterinary Pathologists

ARTICLES

Granulated round cell tumor of cats

M. F. McEntee, S. Horton, J. Blue and D. J. Meuten
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville.

Morphologic and biologic features of five feline granulated round cell tumours were compared with those previously reported to be of globule leukocyte and large granular lymphocyte origin. The five cats ranged from 6 to 9 years of age and presented with nonspecific gastrointestinal signs. Four of the five cats were tested for feline leukemia virus and were negative by enzyme-linked immunosorbent assay. The neoplastic process involved the abdominal cavity in all cases, with a predilection for the distal small intestine and mesentery. The liver and peripheral and thoracic lymphoid tissues were also sporadically affected. Neoplastic round cells contained 0.5-1.5-microns eosinophilic cytoplasmic granules that were difficult to discern on causal observation with hematoxylin and eosin stain but were deep blue and easily visualized when stained with phosphotungstic acid-hematoxylin. In two cases, epithelium in the affected ileum and liver contained unusually large numbers of apparently normal globule leukocytes. Ultrastructurally, the tumor granules tended to cluster at one nuclear pole and were spindle to round in shape with variably dense contents. Some granules contained a dense "cap" at one end or internal crystalloid bars that distorted the granule membrane. The tumors reported herein are similar to all three of the previously reported feline granulated round cell tumors and probably have a common cellular origin.
CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				L. M. Pohlman, M. L. Higginbotham, E. G. Welles, and C. M. Johnson Immunophenotypic and Histologic Classification of 50 Cases of Feline Gastrointestinal Lymphoma Vet. Pathol., March 1, 2009; 46(2): 259 - 268. [Abstract] [Full Text] [PDF]

				M. T. Mandara, G. Ricci, and M. Sforna A cerebral granular cell tumor in a cat. Vet. Pathol., September 1, 2006; 43(5): 797 - 800. [Abstract] [Full Text] [PDF]

				P. Roccabianca, W. Vernau, M. Caniatti, and P. F. Moore Feline Large Granular Lymphocyte (LGL) Lymphoma with Secondary Leukemia: Primary Intestinal Origin with Predominance of a CD3/CD8{alpha}{alpha} Phenotype Vet. Pathol., January 1, 2006; 43(1): 15 - 28. [Abstract] [Full Text] [PDF]

				M. Nagatani, A. Nakamura, Y. Yamaguchi, T. Aikawa, and K. Tamura Spontaneous Eosinophilic Granulated Round Cell Tumors in Rats Vet. Pathol., May 1, 2001; 38(3): 317 - 324. [Abstract] [Full Text] [PDF]

				P. Herraez, B. Berridge, P. Marsh, B. Weeks, and F. Ramiro-Ibanez Small Intestine Large Granular Lymphoma in a Horse Vet. Pathol., March 1, 2001; 38(2): 223 - 226. [Abstract] [Full Text] [PDF]

				R. Miyajima, M. Hosoi, S. Yamamoto, S.-I. Mikami, S. Yamakawa, H. Iwata, and M. Enomoto Eosinophilic Granulated Cells Comprising a Tumor in a Fischer Rat Toxicol Pathol, March 1, 1999; 27(2): 233 - 236. [Abstract] [PDF]