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Veterinary Pathology, Vol 32, Issue 6 713-716, Copyright © 1995 by American College of Veterinary Pathologists

ARTICLES

Localized retroperitoneal fibromatosis causing intestinal obstruction in a cynomolgus monkey (Macaca fascicularis)

J. D. Fikes and M. G. O'Sullivan
Department of Comparative Medicine, Bowman Gray School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1040, USA.

Gross examination of a 24-month-old, male cynomolgus monkey (Macaca fascicularis) revealed obstruction of the ileum by a mass that entrapped and compressed the ileocecal junction. The mass was well circumscribed, firm, and white on cut surface. Histologically, the mass consisted of spindle-shaped cells arranged in interweaving bundles or as narrow cords and individual cells widely separated by dense collagen. A diagnosis of localized retroperitoneal fibromatosis was made based on the characteristic gross and microscopic findings and isolation of type D simian retrovirus, serotype-2, from spleen and mesenteric lymph node. Monkeys with localized retroperitoneal fibromatosis generally exhibit signs only of a palpable mass at the ileocecal junction and/or nonspecific diarrhea. This case represents an unusual presentation of localized retroperitoneal fibromatosis in which the lesion produced intestinal obstruction and death.


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R. E. Guzman, R. L. Kerlin, and T. E. Zimmerman
Histologic Lesions in Cynomolgus Monkeys (Macaca fascicularis) Naturally Infected with Simian Retrovirus Type D: Comparison of Seropositive, Virus-Positive, and Uninfected Animals
Toxicol Pathol, November 1, 1999; 27(6): 672 - 677.
[Abstract] [PDF]


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