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Veterinary Pathology, Vol 33, Issue 1 92-95, Copyright © 1996 by American College of Veterinary Pathologists

ARTICLES

Three cases of carcinoid in the equine nasal cavity and maxillary sinuses: histologic and immunohistochemical features

C. van Maanen, W. R. Klein, K. J. Dik and T. S. van den Ingh
Department of Pathology, Utrecht University, Netherlands.

Three cases of carcinoid tumor in horses are described. The tumors originated from the maxillary sinuses and the retrobulbar region and caused exophthalmos. Histologically, they had a characteristic endocrine pattern and were argyrophilic with the Grimelius stain. All tumors contained reactivity for neuron-specific enolase and synaptophysin. Two of three tumors were reactive for both bovine and porcine chromogranin A. These immunohistochemical results confirm the neuroendocrine nature of these tumors. Neuroendocrine cells could not be detected in the nasal mucosa and maxillary sinuses of a normal horse; therefore, the origin of these carcinoid tumors remains obscure.


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