Vet Pathol Download to Citation Manager
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johnson, G. C.
Right arrow Articles by Turk, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johnson, G. C.
Right arrow Articles by Turk, J. R.

Veterinary Pathology, Vol 33, Issue 2 142-149, Copyright © 1996 by American College of Veterinary Pathologists

ARTICLES

Histologic and immunohistochemical characterization of hemangiomas in the skin of seven young horses

G. C. Johnson, M. A. Miller, J. L. Floss and J. R. Turk
Veterinary Medical Diagnostic Laboratory, University of Missouri, Columbia, USA.

The histologic and immunochemical characteristics of benign vascular tumors excised from the skin of seven young horses were evaluated. The patients were male horses of various breeds and were 16 months of age or younger at the time of presentation. Six tumors occurred on the extremities, and one was removed from the lip. Histologically, most tumors consisted of cellular nodules of varying compactness with few to many blood-filled lumina. Nodular growth separated preexisting adnexa and subcutaneous collagen. Some tumors contained or consisted predominantly of loosely packed arrays of ramifying, veins, and capillaries separated by collagen within the dermis and subcutis. Within areas of nodular growth, multilayered vascular walls were encircled by reticulin strands that surrounded the endothelium and adjacent pericytes and also separated nonperivascular cells in the mass. Immunohistochemical staining of factor-VIII-related antigen and labeling by Ulex europeus-1 lectin was restricted to an innermost layer of cells surrounding vascular spaces, confirming their vascular endothelial origin. The plump fusiform cells arranged concentrically around the endothelium and some of those unassociated with vascular lumina stained with antibody to alpha-smooth muscle actin, as did the muscularis of larger vessels inside and outside of tumor nodules. These findings demonstrate an orderly arrangement between endothelium and supportive cells in these benign vascular neoplasms of young horses, similar to that observed during vascular development.


This article has been cited by other articles:


Home page
 Vet PatholHome page
C. G. Lamm and B. L. Njaa
Ovarian and Intestinal Angiomatosis in a Horse
Vet. Pathol., May 1, 2007; 44(3): 386 - 388.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
M. Y. Gulbahar, H. Yuksel, and L. Aslan
Angiokeratomatous Papilloma Associated with Papillomavirus in a Calf
Vet. Pathol., September 1, 2003; 40(5): 582 - 586.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
R. J. Bildfell, B. A. Valentine, and K. M. Whitney
Cutaneous Vasoproliferative Lesions in Goats
Vet. Pathol., March 1, 2002; 39(2): 273 - 277.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1996 by the American College of Veterinary Pathologists.