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Veterinary Pathology, Vol 33, Issue 2 228-230, Copyright © 1996 by American College of Veterinary Pathologists

ARTICLES

Spontaneous pulmonary squamous cell carcinoma in an aging CD rat

H. C. Chen, C. T. Liang, C. C. Hong, Y. J. Huang and I. J. Pan
National Laboratory Animal Breeding and Research Center, National Science Council, Taipei, Taiwan (ROC).

Naturally occurring squamous cell carcinomas of lung of laboratory rodents are rare, and few cases have been reported and illustrated. A solid peripheral lung mass was observed grossly in a untreated 573-day-old male Sprague Dawley CD (Crl:CD [SD] BR) rat. Microscopically, the mass was composed of neoplastic squamous epithelial cells arranged in nests, cords, nodules, or solid sheets. Epithelial pearls were present. The mitotic index was high, and intercellular bridging (prickles) was noted. In some areas, neoplastic cells rimmed large cystic areas containing neutrophils, cell debris, and laminated keratin masses. Neoplastic cells had both expansive and invasive growth with entrapment of bronchioles and marked fibroplasia.




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Copyright © 1996 by the American College of Veterinary Pathologists.