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Veterinary Pathology, Vol 33, Issue 3 356-359, Copyright © 1996 by American College of Veterinary Pathologists

ARTICLES

Ubiquitin expression in degenerating axons of equine cervical compressive myelopathy

B. S. Jortner, W. K. Scarratt, P. D. Modransky, A. Walton and S. K. Perkins
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061-0442, USA.

Neuropathologic examination revealed axonal swelling and breakdown leading to Wallerian degeneration of affected myelinated nerve fibers in the spinal cord white matter of four young horses with equine cervical compressive myelopathy. Immunohistochemical reactions for the cell stress protein ubiquitin revealed an enhanced presence in the swollen axons, which may reflect a role for ubiquitin in the neuronal catabolic process of axonal compression and degeneration in this myelopathy.


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