Vet Pathol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eaton, K. A.
Right arrow Articles by Wellman, M. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eaton, K. A.
Right arrow Articles by Wellman, M. L.

Veterinary Pathology, Vol 34, Issue 2 117-126, Copyright © 1997 by American College of Veterinary Pathologists

ARTICLES

Autosomal dominant polycystic kidney disease in Persian and Persian-cross cats

K. A. Eaton, D. S. Biller, S. P. DiBartola, M. J. Radin and M. L. Wellman
Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, USA.

A form of autosomal dominant polycystic kidney disease (ADPKD) similar in clinical features to human ADPKD occurs in the Persian cat. We characterized the morphologic and immunohistochemical features of this disease in a colony of affected cats. Complete postmortem examinations were performed on 11 normal and 22 affected cats ranging in age from 3 months to 10 years. Kidneys were evaluated by gross and histologic examinations, ultrastructure, lectin staining, bromodeoxyuridine immunochemistry for labeling index and immunochemistry for distribution of Na/K ATPase. Feline ADPKD was characterized by variable numbers of cysts in the renal cortex and medullar. Ultrastructural examination and lectin staining suggested that cysts arose from proximal and distal nephron segments. Bromodeoxyuridine labeling demonstrated increased proliferation of epithelium lining some cysts in young cats. Immunohistochemical staining showed variable translocation of Na/K ATPase from the basolateral membranes of cyst-lining cells to the cytoplasm or luminal membranes. Cystic renal disease commonly was associated with chronic tubulointerstitial nephritis and hepatobiliary hyperplasia and fibrosis. Focal hyperplasia of renal tubular epithelium, hepatic cysts, and cardiac lesions were present in some cats. Feline ADPKD shares many morphologic and pathogenetic features with human ADPKD.


This article has been cited by other articles:


Home page
 Journal of the American Animal Hospital AssociationHome page
A. Zatelli, P. D'Ippolito, U. Bonfanti, and E. Zini
Ultrasound-Assisted Drainage and Alcoholization of Hepatic and Renal Cysts: 22 Cases
J. Am. Anim. Hosp. Assoc., March 1, 2007; 43(2): 112 - 116.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
H. E. V. De Cock, M. A. Forman, T. B. Farver, and S. L. Marks
Prevalence and Histopathologic Characteristics of Pancreatitis in Cats
Vet. Pathol., January 1, 2007; 44(1): 39 - 49.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L. A. Lyons, D. S. Biller, C. A. Erdman, M. J. Lipinski, A. E. Young, B. A. Roe, B. Qin, and R. A. Grahn
Feline Polycystic Kidney Disease Mutation Identified in PKD1
J. Am. Soc. Nephrol., October 1, 2004; 15(10): 2548 - 2555.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1997 by the American College of Veterinary Pathologists.