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Veterinary Pathology, Vol 34, Issue 2 138-145, Copyright © 1997 by American College of Veterinary Pathologists

ARTICLES

Canine neuroendocrine tumors of the pancreas: a study using image analysis techniques for the discrimination of metastatic versus nonmetastatic tumors

G. Minkus, U. Jutting, M. Aubele, K. Rodenacker, P. Gais, W. Breuer and W. Hermanns
Institute of Pathology, GSF-National Research Center for Environment and Health, Oberschleissheim, Germany.

Canine pancreatic neuroendocrine tumors were studied using different image analysis techniques (nuclear image histometry, analysis of argyrophilic proteins of nucleolar organizer regions, determination of the mouse anti-Ki 67 antigen proliferation index, and DNA densitometry) to correlate their biological behavior with objective phenotypic markers. The methods were compared to determine the best method for distinguishing between metastatic and nonmetastatic tumors. Discrimination between the two types of tumor was possible using nuclear image histometry in combination with morphometric analysis of argyrophilic proteins of nucleolar organizer regions. In contrast, the mouse anti-Ki 67 antigen proliferation index, DNA measurement, and immunohistochemical parameters revealed no significant difference between the two types of tumors.




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Copyright © 1997 by the American College of Veterinary Pathologists.