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Primary Epitheliotropic T-cell Lymphoma of the Urinary Bladder in a Dog

Abstract

A 7-year-old, intact female mixed-breed dog was presented for evaluation of hematuria. Physical examination revealed a suprapubic mass. Ultrasonographic examination showed a large lobular mass occupying the urinary bladder. At the owners' request, the dog was euthanatized and a postmortem examination was performed. Necropsy confirmed the presence of a lobular mass of about 5- to 6-cm diameter protruding into the lumen of the bladder. Histologically, the mass was composed of a large number of atypical lymphoid cells in the lamina propria and mucosal epithelium. Immunohistochemically, the neoplastic cells expressed CD3 but not CD79 or keratin and vimentin, supporting a diagnosis of T-cell lymphoma.

Key words: Dogs; epitheliotropism; urinary bladder; T-cell lymphoma.

Request reprints from Dr. P. Maiolino, Dipartimento di Patologia e Sanità Animale, Settore Anatomia Patologica, Facoltà di Medicina Veterinaria, Università degli Studi di Napoli Federico II, Via Delpino, 1-80137 Napoli (Italy) and from Prof. G. DeVico, Instituto di Patologia Generale ed Anatomia Patologia, Facoltà di Medicina Veterinaria, Università degli Studi di Messina, Via S. Cecilia, 30-98123 Messina (Italy).

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