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Vet Pathol 37:364-369 (2000)
© 2000 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Multiple Myeloma in Cats: Variable Presentation with Different Immunoglobulin Isotypes in Two Cats

D. Bienzle, D. C. Silverstein and K. Chaffin

Abstract

Multiple myeloma was diagnosed in two cats with monoclonal hyperglobulinemia, proteinuria, and plasma cell proliferations in bone marrow. An immunoglobulin G-producing myeloma occurred in the vertebral bone marrow of one cat, and twice responded to surgical reduction followed by a combination of local irradiation and chemotherapy. The cat's survival time was approximately 2 years. The other myeloma in a cat that presented with hypercalcemia and renal insufficieny involved visceral organs and produced a biclonal peak due to immunoglobulin A dimer formation on serum electrophoresis. This cat's tumor did not respond to chemotherapy.

Key words: B cell neoplasia; monoclonal gammopathy; multiple myeloma.

Request reprints from Dr. D. Bienzle, Department of Pathobiology, University of Guelph, Guelph, ON, N1H 2W1 (Canada).




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O. Yamada, K. Tamura, H. Yagihara, M. Isotani, M. Azakami, S. Sawada, K. Ono, T. Washizu, and M. Bonkobara
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[Abstract] [Full Text] [PDF]


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