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Multiple Myeloma in Cats: Variable Presentation with Different Immunoglobulin Isotypes in Two Cats

Abstract

Multiple myeloma was diagnosed in two cats with monoclonal hyperglobulinemia, proteinuria, and plasma cell proliferations in bone marrow. An immunoglobulin G-producing myeloma occurred in the vertebral bone marrow of one cat, and twice responded to surgical reduction followed by a combination of local irradiation and chemotherapy. The cat's survival time was approximately 2 years. The other myeloma in a cat that presented with hypercalcemia and renal insufficieny involved visceral organs and produced a biclonal peak due to immunoglobulin A dimer formation on serum electrophoresis. This cat's tumor did not respond to chemotherapy.

Key words: B cell neoplasia; monoclonal gammopathy; multiple myeloma.

Request reprints from Dr. D. Bienzle, Department of Pathobiology, University of Guelph, Guelph, ON, N1H 2W1 (Canada).

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