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Vet Pathol 37:422-427 (2000)
© 2000 American College of Veterinary Pathologists

Persistent Hyperplastic Tunica Vasculosa Lentis and Persistent Hyperplastic Primary Vitreous in Transgenic Line TgN3261Rpw

C. M. H. Colitz, D. E. Malarkey, R. P. Woychik and J. E. Wilkinson

Departments of Companion Animal and Special Species Medicine (CMHC 1) and Microbiology, Pathology, and Parasitology (DEM), North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC; Oak Ridge National Laboratory, Biology Division, Oak Ridge, TN (RPW ,2); and Department of Pathology, University of Tennessee, College of Veterinary Medicine, PO Box 1071, Knoxville, TN (JEW)

Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous are congenital ocular anomalies that can lead to cataract formation. A line of insertional mutant mice, TgN3261Rpw, generated at the Oak Ridge National Laboratory in a large-scale insertional mutagenesis program was found to have a low incidence (8/243; 3.29%) of multiple developmental ocular abnormalities. The ocular abnormalities include persistent hyperplastic primary vitreous, persistent hyperplastic tunica vasculosa lentis, failure of cleavage of the anterior segment, retrolental fibrovascular membrane, posterior polar cataract, and detached retina. This transgenic mouse line provides an ontogenetic model because of the high degree of similarity of this entity in humans, dogs, and mice.

Key words: Embryology; eye; mice; persistent hyperplastic primary vitreous; persistent hyperplastic tunica vasculosa lentis.

Request reprints from Dr. Carmen M. H. Colitz, Louisiana State University, School of Veterinary Medicine, Department of Veterinary Clinical Sciences, South Stadium Drive, Baton Rouge, LA 70803 (USA).


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