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Oral Focal Epithelial Hyperplasia in a Howler Monkey (Alouatta fusca)

Abstract

Oral focal epithelial hyperplasia is a rare and seldom reported disease in animals and humans induced by a papillomavirus. The present report is the first description of this disease in a Neotropical primate, a howler monkey (Alouatta fusca). The diagnosis was based on gross and microscopic findings. The generic papillomavirus antigen was identified by immunohistochemistry and was found not to be related to any human papillomavirus DNA tested by in situ hybridization. This virus is probably a specific papillomavirus of the howler monkey (HMPV).

Key words: Focal epithelial hyperplasia; howler monkeys; immunohistochemistry; in situ hybridization; Neotropical primates; oral cavity; papillomavirus.

Request reprints from Dr. L. R. M. de Sá, Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Av. Prof. Dr. Orlando Marques de Paiva, 87, CEP 05508-900, Cidade Universitária, São Paulo, (Brasil). E-mail: liliansa{at}osite.com.br.