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Anti-plakin and Desmoglein Autoantibodies in a Dog with Pemphigus Vulgaris

Abstract

Paraneoplastic pemphigus was suspected in a 14-year-old Labrador retriever because of mucocutaneous erosions, microscopic suprabasal acantholysis, and keratinocyte apoptosis. In this patient, circulating IgG autoantibodies recognized plakin (envoplakin, periplakin) and desmoglein (desmoglein-1 and -3) antigens. Necropsy, however, failed to confirm the concurrent existence of hematopoietic or solid neoplasia. The diagnosis of pemphigus vulgaris therefore was proposed. This study illustrates that such a combination of clinicopathologic lesions and plakin/desmoglein-specific autoantibodies is not restricted to canine paraneoplastic pemphigus but can also be detected in another form of suprabasal pemphigus.

Key words: Autoimmunity; blistering dermatoses; dogs; skin.

Request reprints from Dr. T. Olivry, Deparment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606 (USA). E-mail: Thierry_Olivry{at}ncsu.edu.

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				S. A. Elmore, J. Basseches, G. J. Anhalt, J. M. Cullen, and T. Olivry Paraneoplastic Pemphigus in a Dog with Splenic Sarcoma Vet. Pathol., January 1, 2005; 42(1): 88 - 91. [Abstract] [Full Text] [PDF]