This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Olivry, T. Articles by Ghohestani, R. F. Search for Related Content PubMed PubMed Citation Articles by Olivry, T. Articles by Ghohestani, R. F. Social Bookmarking                            What's this?

Anti-plakin and Desmoglein Autoantibodies in a Dog with Pemphigus Vulgaris

Abstract

Paraneoplastic pemphigus was suspected in a 14-year-old Labrador retriever because of mucocutaneous erosions, microscopic suprabasal acantholysis, and keratinocyte apoptosis. In this patient, circulating IgG autoantibodies recognized plakin (envoplakin, periplakin) and desmoglein (desmoglein-1 and -3) antigens. Necropsy, however, failed to confirm the concurrent existence of hematopoietic or solid neoplasia. The diagnosis of pemphigus vulgaris therefore was proposed. This study illustrates that such a combination of clinicopathologic lesions and plakin/desmoglein-specific autoantibodies is not restricted to canine paraneoplastic pemphigus but can also be detected in another form of suprabasal pemphigus.

Key words: Autoimmunity; blistering dermatoses; dogs; skin.

Request reprints from Dr. T. Olivry, Deparment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606 (USA). E-mail: Thierry_Olivry{at}ncsu.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. A. Elmore, J. Basseches, G. J. Anhalt, J. M. Cullen, and T. Olivry Paraneoplastic Pemphigus in a Dog with Splenic Sarcoma Vet. Pathol., January 1, 2005; 42(1): 88 - 91. [Abstract] [Full Text] [PDF]