Vet Pathol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haechler, S.
Right arrow Articles by Welle, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haechler, S.
Right arrow Articles by Welle, M.
Vet Pathol 37:669-671 (2000)
© 2000 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Congenital Hepatic Fibrosis and Cystic Bile Duct Formation in Swiss Freiberger Horses

S. Haechler, T. S. G. A. M. Van Den Ingh, C. Rogivue, F. Ehrensperger and M. Welle

Abstract

Congenital hepatic fibrosis with autosomal recessive or dominant inheritance has been described in humans, cats, piglets, and dogs. In horses, only two cases of congenital hepatic fibrosis have been previously reported. This retrospective study of records from the Institute for Animal Pathology, University of Berne, identified 30 foals with liver lesions compatible with congenital hepatic fibrosis. Anamnestic data revealed clinical signs of severe liver injury in most affected animals. Pathologic examination showed severely enlarged, firm livers with thin-walled cysts. Histologically, the livers showed diffuse porto-portal bridging fibrosis with many small, irregularly formed and sometimes cystic bile ducts. All foals belonged to the Swiss Freiberger breed. Pedigree analysis revealed that the diseased animals could be traced back to one stallion. These results strongly suggest that congenital hepatic fibrosis in Swiss Freiberger horses is a recessively inherited autosomal genetic defect.

Key words: Congenital hepatic fibrosis; cystic bile duct formation; hereditary diseases; horses; Liver.

Request reprints from Dr. M. Welle, Institut für Tierpathologie, Universität Bern, Länggass-Str. 122, CH-3012 Bern (Switzerland). E-mail: monika.welle{at}itpa.unibe.ch.




This article has been cited by other articles:


Home page
 Vet PatholHome page
D. L. Brown, M. Anderson, and J. M. Cullen
Mesenchymal Hamartoma of the Liver in a Late-Term Equine Fetus
Vet. Pathol., January 1, 2007; 44(1): 100 - 102.
[Abstract] [Full Text] [PDF]

Home page
 Vet PatholHome page
A. Salvaggio, S. Caracappa, A. Gurrera, and G. Magro
Hepatic Biliary Adenofibroma: A Hitherto Unrecognized Tumor in Equines. Report of a Case
Vet. Pathol., January 1, 2003; 40(1): 114 - 116.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American College of Veterinary Pathologists.