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Vet Pathol 38:20-30 (2001)
© 2001 American College of Veterinary Pathologists
ANIMAL MODELS

Special Considerations in the Evaluation of the Hematology and Hemostasis of Mutant Mice

B. D. Car and V. M. Eng

DuPont Pharmaceuticals Company, Stine–Haskell Research Center, Haskell-1, P.O. Box 30, Newark, DE (BDC); and University of Pennsylvania, University Laboratory Animal Resources, Philadelphia, PA (VME)

The study of mutant mice with altered or deficient hematopoietic or hemostatic gene products provides a challenge to the researcher, particularly when genetic alterations lead to lethal phenotypes. The following review provides a framework for understanding murine hematopoiesis, based on work with mutant mice, and details experimental approaches used to evaluate these animals. Mice with deficiencies in hemostatic and fibrinolytic system proteins are discussed, and the investigation of their phenotypes is reviewed.

Key words: Coagulation; fibrinolysis; hematology; hematopoiesis; hemostasis; knockout; mice.

Request reprints from Dr. Bruce D. Car, DuPont Pharmaceuticals Company, Stine–Haskell Research Center, Haskell-1, P.O. Box 30, Newark, DE 19714-0030 (USA). E-mail: bruce.d.car{at}dupontpharma.com.




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Copyright © 2001 by the American College of Veterinary Pathologists.