This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Scruggs, D. W. Articles by Sorden, S. D. Search for Related Content PubMed PubMed Citation Articles by Scruggs, D. W. Articles by Sorden, S. D. Social Bookmarking                            What's this?

Proliferative Vasculopathy and Cutaneous Hemorrhages in Porcine Neonates Infected with the Porcine Reproductive and Respiratory Syndrome Virus

Abstract

Severe cutaneous hemorrhages with dermal and subcutaneous capillary angioplasia were seen in aborted and stillborn piglets, concurrently with an acute outbreak of porcine reproductive and respiratory syndrome virus (PRRSV) abortions. Histologically, the lesions consisted of angioblastic endothelial cells and immature capillary vascular structures coursing through the edematous myxomatous dermis and subcutis. Proliferating capillaries often were surrounded by large and foamy macrophages that stained positively for PRRSV by immunohistochemistry. The sudden appearance of these vascular lesions during the PRRSV outbreak and their abrupt disappearance after the abortion storm, along with the immunohistochemical localization of PRRSV-positive macrophages adjacent to the proliferating capillaries, suggest that PRRSV likely played a role in the development of these unusual lesions.

Key words: Abortion; angioplasia; cutaneous hemorrhages; porcine viruses; PRRS virus.

Request reprints from Daniel W. Scruggs, Diagnostic and Field Services, College of Veterinary Medicine, PO Box 9825, Mississippi State, MS 39762 (USA). Email: dscruggs{at}cvm.msstate.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?