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Vet Pathol 38:343-346 (2001)
© 2001 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Granulomatous Enteritis and Lymphadenitis in Iberian Pigs Naturally Infected with Lawsonia intracellularis

J. Segalés, J. M. Fernández-Salguero, G. Fructuoso, J. Quintana, C. Rosell, J. Pozo, M. L. De Arriba, P. Rubio and M. Domingo

Abstract

Intestinal samples and/or lymph nodes of two Iberian pigs from two different farms were submitted for histopathologic examination. Both pigs had proliferation of ileal and/or cecal crypts with almost complete absence of goblet cells. Infection by Lawsonia intracellularis was demonstrated by immunohistochemistry and polymerase chain reaction assay. The mesenteric lymph node of one pig had moderate lymphocyte depletion with granulomatous inflammation of the lymph node parenchyma. Histiocytes and multinucleated giant cells from the lymph node of one pig contained L. intracellularis antigen within the cytoplasm. This pig had also porcine circovirus type 2 (PCV-2) infection, but nucleic acid and antigen of this virus were not demonstrated in the lymph node. The second pig had lymphocyte depletion and marked granulomatous inflammation in Peyer's patches. Histiocytes and multinucleated giant cells in areas of granulomatous inflammation contained L. intracellularis antigen; no PCV-2 nucleic acid or antigen was detected in the tissues of this pig. This is the first description of granulomatous ileitis and lymphadenitis associated with L. intracellularis infection.

Key words: Granulomatous inflammation; Iberian pigs; immunohistochemistry; Lawsonia intracellularis.

Request reprints from Dr. J. Segalés, Centre de Recerca en Sanitat Animal (CReSA)—Department de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona (Spain). Email: Joaquim.Segales{at}uab.es.






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