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Vet Pathol 38:470-473 (2001)
© 2001 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Spontaneous Complex Pheochromocytoma in a Fischer 344 Rat

M. J. Martinez and S. R. Mog

Abstract

A spontaneous complex pheochromocytoma was diagnosed in the adrenal gland of an aged female Fischer 344 rat. This expansile neoplasm consisted of pheochromocytoma and areas of ganglioneuroma. The supporting stroma of both neoplastic components contained spindle-shaped cells, which also formed large fascicles. Immunohistochemically, pheochromocytoma cells stained for synaptophysin and chromogranin, scattered ganglioneuroma cells stained for neurofilament protein, and the spindle-shaped stromal cells were positive for S-100 protein. Special stains demonstrated Nissl substance in the ganglioneuroma cells and nerve fibers in the fascicles.

Key words: Adrenal gland neoplasms; ganglioneuroma; immunohistochemistry; neural crest; pheochromocytoma; rats.

Request reprints from M. J. Martinez, USAMRIID, 1425 Porter St., Fort Detrick, MD 21702-5011 (USA), Attn: MCMR-UIP.




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