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Metastatic Lymphangiosarcoma in a Horse

Abstract

A lymphangiosarcoma with metastases was found in a horse that presented with respiratory distress and edema in the ventral thorax and abdomen. The necropsy revealed diffuse edema in the subcutaneous connective tissue. Mediastinal, mesenteric, iliac, and renal lymph nodes were enlarged and white with soft, yellowish necrotic areas. Histologic examination revealed numerous channels and disorganized vessels lined by large polyhedral, polymorphic cells. Tumor metastases were observed in the spleen, lungs, and kidneys. Immunohistochemical evaluation of the tumor cells demonstrated positive staining for factor VIII, vimentin, and keratin. Laminin was scarce, and collagen IV staining was negative, consistent with a discontinuous or absent basement membrane.

Key words: Horses; immunohistochemistry; metastatic lymphangiosarcoma.

Request reprints from Dr. J. Flores, Departamento de Patologia Animal II, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid (Spain). E-mail: jflores{at}vet.ucm.es.

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				C. Puff, V. Herder, A. Philipp, and W. Baumgartner Lymphangiosarcoma in the nictitating membrane of a horse J Vet Diagn Invest, January 1, 2008; 20(1): 108 - 110. [Abstract] [Full Text] [PDF]