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Vet Pathol 39:269-273 (2002)
© 2002 American College of Veterinary Pathologists
CASE REPORTS AND BRIEF COMMUNICATIONS

Encephalomyelitis Associated with Akabane Virus Infection in Adult Cows

J. K. Lee, J. S. Park, J. H. Choi, B. K. Park, B. C. Lee, W. S. Hwang, J. H. Kim, Y. H. Jean, M. Haritani, H. S. Yoo and D. Y. Kim

Abstract

Between August and September 2000, five 2–7-year-old cows in Korea exhibited neurologic signs and were diagnosed as infected with Akabane virus based on the results of histopathology, immunohistochemistry, serology, and reverse transcription polymerase chain reaction (RT-PCR) analysis. Immunohistochemistry and RT-PCR were equally effective and sensitive for diagnosing Akabane virus infection during the early stage of infection. Typical lymphohistiocytic inflammation characterized by perivascular mononuclear cell infiltration, gliosis, neuronophagia, and neuronal loss was noted in the brain and the ventral horn gray matter of the spinal cord. The lesions in the brain were most prominent in the pons and medulla oblongata. Akabane virus antigen was detected in the brain and spinal cord, mainly in degenerating neurons and glial cells. RT-PCR analysis revealed a target band of expected size in four cows. This is the first report on an outbreak of natural Akabane virus infection in adult cattle.

Key words: Akabane virus; cattle; immunohistochemistry; RT-PCR.

Request reprints from Dr. D-Y. Kim, Department of Veterinary Pathology, College of Veterinary Medicine, Seoul National University, Suwon 441-744 (Korea). E-mail: daeyong{at}plaza.snu.ac.kr.




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Copyright © 2002 by the American College of Veterinary Pathologists.