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Vet Pathol 39:390-392 (2002)
© 2002 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

A Variant of Pulmonary Alveolar Microlithiasis in nackt Mice

M. F. Starost, F. Benavides and C. J. Conti

Abstract

Four adult mutant nackt mice, which demonstrate alopecia and CD4+ T-cell deficiency, and two outbred SENCAR mice (sentinels) were presented for routine health surveillance. Lesions were not observed at necropsy. Microscopically, all four nackt mice demonstrated multiple concretions that were 30–100 µm in diameter, irregularly rounded to oval, nonbirefringent, and amphophilic to basophilic. Many of the concretions appeared attached to or within the alveolar walls of all lung lobes. Approximately half of the concretions had irregular fracture lines. All concretions were periodic acid–Schiff positive, and Von Kassa staining revealed diffuse calcification. None of the concretions were associated with inflammatory cell infiltrates, and metaplastic ossification was not evident. A diagnosis of pulmonary alveolar microlithiasis, a rare disease in both humans and animals, was made based on the size and location of the concretions and the lack of an inflammatory response. This is the first report of a laboratory mouse demonstrating pulmonary alveolar microlithiasis.

Key words: Lung; mutant mice; nackt mice; pulmonary alveolar microlithiasis.

Request reprints from Dr. M. Starost, University of Texas M.D. Anderson Cancer Center, Department of Veterinary Sciences, 650 Cool Water Drive, Bastrop, TX 78602 (USA). E-mail: mstarost{at}mdanderson.org.




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