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Intracranial Lymphomas in Simian Retrovirus-Positive Macaca fascicularis

Abstract

Two young adult Macaca fascicularis each had unilateral mydriasis and ptosis. Both animals were euthanatized, monkey No. 1 for progressive neurologic signs and monkey No. 2 because of a positive intradermal tuberculin test. At necropsy, each animal had a single intracranial mass on the ventral surface of the midbrain, surrounding the oculomotor nerve. Histologically, both masses were immunoblastic lymphomas. Immunohistochemical staining revealed the neoplasms to be of B-cell origin. Simian retrovirus (SRV) was isolated from both monkeys, but simian immunodeficiency virus was not found. Both animals lacked antibody to SRV. Both animals had antibodies to Epstein–Barr–like virus (EBV), but EBV antigens were not found by immunohistochemistry. Polymerase chain reaction analysis for integrated EBV DNA was unproductive. One of the animals (monkey No. 2) had a pulmonary infection with Mycobacterium avium, suggesting that immunosuppression was present. These cases represent a unique and previously undescribed type of solitary lymphoma in SRV-infected macaques.

Key words: B-Cell lymphoma; immunodeficiency; intracranial lymphoma; Macaca fascicularis; simian retroviruses.

Request reprints from Dr. J. M. Cline, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston–Salem, NC 27157 (USA). E-mail: jmcline{at}wfubmc.edu.