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Vet Pathol 39:445-451 (2002)
© 2002 American College of Veterinary Pathologists

Immunohistochemical Characterization of Tumor Cells and Inflammatory Infiltrate Associated with Cutaneous Melanocytic Tumors of Duroc and Iberian Swine

J. Pérez, P. M. García, M. J. Bautista, Y. Millán, J. Ordás and J. Martín de las Mulas

Department of Comparative Pathology, Faculty of Veterinary Medicine, Campus de Rabanales, Córdoba, Spain

The immunophenotype of tumor cells and inflammatory infiltrate associated with cutaneous melanocytic lesions (29 melanocytomas, two malignant melanomas, and 23 residual lesions) from 54 adult Iberian and Iberian x Duroc pigs were examined using a panel of nine antibodies. All neoplastic cells were vimentin+, cytokeratin-, and alpha-1-antitrypsin- and the majority were S100+, whereas all pigmented macrophages were vimentin+, cytokeratin-, and S100- and most expressed alpha-1-antitrypsin. Regressing tumors were characterized by zones with low density of neoplastic cells accompanied by heavy infiltration of CD3+ T lymphocytes, whereas zones with high density of neoplastic cells showed very low numbers of CD3+ T lymphocytes. The infiltrate of CD79a+ B cells and IgG, IgM, and IgA plasma cells was low. The majority of lymphocytes of the peri- and intratumoral infiltrate were major histocompatibility complex class II+, but neoplastic cells did not express class II antigen. The 17 residual lesions examined were composed of macrophages containing abundant melanin pigment and low to moderate numbers of CD3+ T lymphocytes. The results of the present study suggest that the local cellular immune response plays a crucial role in the host response that induces regression of cutaneous melanomas and melanocytomas of the Iberian and crossbred Iberian x Duroc pigs.

Key words: Immunohistochemistry; melanoma; skin; swine; tumor regression.

Request reprints from Dr. J. Pérez, Departamento de Anatomía y Anatomía Patológica Comparadas, Edificio de Sanidad Animal, Campus de Rabanales, Ctra. Madrid Cádiz km 396, 14014 Córdoba, (Spain). E-mail: an1pearj{at}uco.es.




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