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Hepatosplenic T-cell Lymphoma in a Mare

Abstract

A 21-year-old Dutch crossbred mare was presented with a 1-month history of weight loss and weakness. Clinical evaluation revealed severe anemia and thrombocytopenia with evidence of hepatic disease and muscular damage. Necropsy findings included diaphragmatic rupture with an extensive retroperitoneal hematoma and severe hepatosplenomegaly. Microscopic findings were characterized by hepatic sinusoidal and splenic red pulp infiltration by atypical CD3-positive lymphocytes. No other nodal or extranodal sites were affected. Hepatosplenic lymphoma with a probable T-cell origin was diagnosed based on gross and histologic findings.

Key words: Hepatosplenic disease; horses; immunohistochemistry; lymphoma; phenotype; T cell.

Requests reprints from Dr. P. Roccabianca, Dipartimento di Patologia Animale, Igiene e Sanita' Pubblica-Sezione Anatomia Patologica e Patologia Aviare, Facolta' di Medicina Veterinaria, Via Celoria 10, 20133 Milano (Italy). E-mail: paola.roccabianca{at}unimi.it.

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