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Ganglioradiculitis (Sensory Neuronopathy) in a Dog: Clinical, Morphologic, and Immunohistochemical Findings

Abstract

A 9-year-old Labrador Retriever was diagnosed with ganglioradiculitis (sensory neuronopathy). This idiopathic disease of mature dogs is characterized by a profound loss of sensory nerve function due to mononuclear inflammatory infiltration of peripheral ganglia and spinal nerve roots, with destruction of sensory neurons. Immunohistochemistry demonstrates that the infiltrating cells are primarily T lymphocytes and that immunoglobulins are not present on the cell membranes of affected neurons. The pathogenesis of ganglioradiculitis remains unclear, but the evidence points to a cell-mediated immune mechanism.

Key words: Autoimmunity; dogs; ganglia; ganglioradiculitis; immunohistochemistry; nervous system; sensory neuron.

Request reprints from Dr. B. Porter, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, S2118 Schurman Hall, Ithaca, NY 14583 (USA). E-mail: bp45{at}cornell.edu.