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Vet Pathol 39:739-743 (2002)
© 2002 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Spontaneous Basaloid Adenomas of the Mammary Gland in Four Dogs: Clinicopathologic and Immunohistochemical Features

J. Martín de las Mulas, J. Ordás, M. Y. Millán, A. Espinosa de los Monteros and C. Reymundo

Abstract

Spontaneous basaloid adenomas occurred in four out of 354 dogs with mammary tumors. Affected dogs were pure-bred, intact females between 6 and 8 years of age. Three dogs were nuliparous, two had pseudopregnancies, and none had received contraceptive steroids. The tumors were multiple (three cases) or unique, less than 1 cm in diameter, well delineated, and composed of uniform cords and clusters of monomorphic epithelial cells with focal signs of squamous or glandular differentiation. A basal cell immunophenotype (cytokeratins 5 and 14 positive) without either glandular epithelial (cytokeratins 8, 18, and 19 negative) or myoepithelial (calponin negative) differentiation was observed in the majority of tumor cells. No recurrence or metastasis was recorded after follow-up periods between 3 and 24 months. In spite of the hormone-dependent nature of this tumor in female Beagles given experimental contraceptive steroids, spontaneous basaloid adenomas lacked estrogen receptor alpha and progesterone receptors.

Key words: Basaloid adenoma; dogs; immunohistochemistry; mammary gland.

Request reprints from Prof. Juana Martín de las Mulas, Departamento de A. y Anatomía Patológica Comparadas, Universidad de Córdoba, Edificio de Sanidad Animal, Campus de Rabanales, Carretera de Madrid-Cádiz, Km. 396, 14014 Córdoba (Spain). E-mail: an1magoj{at}uco.es.


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F. Sassi, G. Sarli, B. Brunetti, F. Morandi, and C. Benazzi
Immunohistochemical characterization of mammary squamous cell carcinoma of the dog
J Vet Diagn Invest, November 1, 2008; 20(6): 766 - 773.
[Abstract] [Full Text] [PDF]


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