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Vet Pathol 39:751-756 (2002)
© 2002 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Harlequin Ichthyosis in Two Greater Kudu (Tragelaphus strepsiceros)

E. J. Chittick, T. Olivry, F. Dalldorf, J. Wright, B. A. Dale and B. A. Wolfe

Abstract

Two greater kudu calves (Tragelaphus strepsiceros) born 7 years apart were found with fissures and thickened, scaly, cutaneous plates covering over 80% of their bodies. One was dead at presentation, and the other was euthanized shortly after birth. Both animals shared a common sire. On necropsy, chemosis, ectropion, eclabium, and bilateral valgus deformities of the tarsal joints were observed in one calf, presumed to be secondary to the plates restricting normal fetal development. The principal microscopic lesion was severe lamellar orthokeratosis, with focal mild parakeratosis. Ultrastructural epidermal lesions included the absence of normal lamellar granules, large dilated endoplasmic reticulum, and abnormal retention of organelles and vesicles. Gross, histopathologic, and electron microscopic findings in both kudu calves were consistent with those of harlequin ichthyosis, a rare dermatosis of humans believed to have an autosomal recessive inheritance pattern. The underlying genetic and molecular abnormality and heritability of this condition in this greater kudu herd were not determined.

Key words: Greater kudus; harlequin ichthyosis; histopathology; skin; ultrastructure.

Request reprints from Dr. Barbara Wolfe, North Carolina Zoological Park, 4401 Zoo Parkway, Asheboro, NC 27203 (USA). E-mail: Barbara.Wolfe{at}ncmail.net.




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