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Vet Pathol 40:86-91 (2003)
© 2003 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Invasive Ductal Carcinoma of the Mammary Gland in a Mare

K. Hirayama, Y. Honda, T. Sako, M. Okamoto, N. Tsunoda, M. Tagami and H. Taniyama

Abstract

A 21-year-old thoroughbred mare had a 35 x 14 x 10 cm mass involving the mammary gland. Metastases were found in the kidneys, lungs, skeletal muscles, and regional lymph nodes. Histopathologic examination of the tumor revealed a ductal solid carcinoma with extensive intraductal and intralobular involvement and focal infiltration of the adjacent stroma. The intralobular neoplasms were divided into irregularly shaped islands and sheets of polygonal and spindle-shaped epithelial cells by thick or thin fibrous connective tissue bundles. The neoplastic cells had a small or moderate amount of cytoplasm that stained faintly with eosin and round or oval hyperchromatic nuclei. Immunohistochemically, the neoplastic cells were strongly positive for Lu-5, weakly positive for AE1/AE3, vimentin, and glial fibrillary acidic protein, and negative for cytokeratin 8, cytokeratin 14, {alpha}-smooth muscle actin, calponin, and S100. The neoplasm was diagnosed as an invasive ductal carcinoma of the mammary gland with multiple metastases.

Key words: Ductal carcinoma; horses; immunohistochemistry; mammary gland.

Request reprints from Dr. H. Taniyama, Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Bunkyodai-Midorimachi 582, Ebetsu, Hokkaido 069-8501 (Japan).


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