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Vet Pathol 40:207-212 (2003)
© 2003 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Cyclooxygenase-2 Expression in Canine Mammary Tumors

M. Doré, I. Lanthier and J. Sirois

Abstract

Mammary tumors are the most common neoplasms in female dogs. Induction of cyclooxygenase-2 (COX-2) has been implicated in various cancers in humans. However, expression of COX-2 has not been investigated in canine mammary tumors. Normal mammary gland (n = 4), simple or complex adenomas (n = 63), and simple or complex adenocarcinomas (n = 84) were studied by immunohistochemistry. Results showed that COX-2 was not expressed in the normal gland but was detected in 24% of adenomas and in 56% of adenocarcinomas (P < 0.001). The incidence of COX-2 expression and the intensity of the COX-2 signal were higher in adenocarcinomas than in adenomas (P < 0.001). These results demonstrate for the first time that COX-2 is induced in a proportion of canine mammary tumors and that COX-2 expression is more frequent and more intense in malignant than in benign tumors, suggesting a potential role for COX-2 in canine mammary tumorigenesis.

Key words: Cyclooxygenase-2; dogs; mammary tumors; prostaglandins.

Request reprints from Dr. M. Doré, Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, St-Hyacinthe, Québec (Canada J2S 7C6). E-mail: doremo{at}medvet.umontreal.ca.




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