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Vet Pathol 40:263-267 (2003)
© 2003 American College of Veterinary Pathologists

Experimental Infection of Equine Herpesvirus 9 in Dogs

T. Yanai, N. Fujishima, H. Fukushi, A. Hirata, H. Sakai and T. Masegi

Department of Veterinary Pathology and Microbiology, Faculty of Agriculture, Gifu University, Gifu, Japan

Equine herpesvirus 9 (EHV-9), a new neurotropic equine herpesvirus, was inoculated intranasally at 107 plaque-forming units in five dogs to assess its pathogenicity. Dogs showed weight loss, pyrexia, anorexia, and neurologic signs on the fourth day. The EHV-9 virus was recovered from the examined brains. Histologically, dogs had a fulminant nonsuppurative encephalitis characterized by severe neuronal degeneration and loss, with intranuclear inclusions, slight glial reactions, perivascular cuffing, and multifocal hemorrhage. The olfactory bulb and the frontal and temporal lobes were predominantly affected. Immunohistochemistry revealed reactivity for EHV-9 antigen in neurons. All dogs had mild bronchopneumonia and various degrees of lymphoid necrosis. These findings indicate that dogs are fully susceptible to EHV-9 and that EHV-9 can cause fulminant encephalitis with high mortality in dogs, as in gazelles and goats.

Key words: Dogs; EHV-9; infectivity; nasal infection.

Request reprints from Dr. T. Yanai, Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, 1–1 Yanagido, Gifu 501-1193 (Japan). E-mail: yanai{at}cc.gifu-u.ac.jp.




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[Abstract] [Full Text] [PDF]


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