| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Department of General Pathology, School of Veterinary Medicine, National University of Rosario, Casilda, Santa Fe, Argentina (JS, MA); Section of Epidemiology and Preventive Medicine, Veterinary Faculty, University of Las Palmas de Gran Canaria, Gran Canaria, Spain (ASR); Department of Comparative Pathology, Veterinary Faculty, University of Las Palmas de Gran Canaria, Gran Canaria, Spain (AF, HL, PH, FR); and Department of Pathological Anatomy, Veterinary Faculty, University of Córdoba, Spain (JCGV, AJ)
Porcine enzootic pneumonia (PEN), caused by Mycoplasma hyopneumoniae (Mh), has been described in pigs in all geographic areas. The disease is characterized by high morbidity and low mortality rates in intensive swine production systems. A morphologic and immunohistochemical study was done to determine the cellular populations present in lung parenchyma of infected pigs, with special attention to the bronchus-associated lymphoid tissue (BALT). Polyclonal and monoclonal antibodies were used for the detection of antigens of Mh, T lymphocytes (CD3+, CD4+, and CD8+), IgG+ or IgA+ lymphocytes, and cells containing lysozyme, S-100 protein, major histocompatibility complex class II antigen or myeloid-histiocyte antigen. Findings in lung tissues associated with Mh infection were catarrhal bronchointerstitial pneumonia, with infiltration of inflammatory cells in the lamina propria of bronchi and bronchioles and alveolar septa. Hyperplasia of mononuclear cells in the BALT areas was the most significant histologic change. The BALT showed a high morphologic and cellular organization. Macrophages and B lymphocytes were the main cellular components of germinal centers. T lymphocytes were primarily located in perifollicular areas of the BALT, lamina propria and within the airway epithelium, and plasma cells containing IgG or IgA at the periphery of the BALT, in the lamina propria of bronchi and bronchioles, in alveolar septa, and around bronchial submucosal glands. The hyperplastic BALT in PEN cases consisted of macrophages, dendritic cells, T and B lymphocytes, and IgG+ and IgA+ plasma cells. CD4+ cells predominated over CD8+ cells. Local humoral immunity appears to play an important role in the infection.
Key words: Bronchus-associated lymphoid tissue; immune response; immunohistochemistry; Mycoplasma hyopneumoniae; pigs.
Request reprints from Dr. F. Rodríguez, Department of Comparative Pathology, Veterinary Faculty, University of Las Palmas de Gran Canaria, Trasmontaña, 35416 Arucas, Gran Canaria (Spain). E-mail: frguez{at}cicei.ulpgc.es.
This article has been cited by other articles:
 |
|
 |
|
  E. R. Schafer, M. J. Oneal, M. L. Madsen, and F. C. Minion Global transcriptional analysis of Mycoplasma hyopneumoniae following exposure to hydrogen peroxide Microbiology, November 1, 2007; 153(11): 3785 - 3790. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R. Okamba, E. Moreau, K. Cheikh Saad Bouh, C. A. Gagnon, B. Massie, and M. Arella Immune Responses Induced by Replication-Defective Adenovirus Expressing the C-Terminal Portion of the Mycoplasma hyopneumoniae P97 Adhesin Clin. Vaccine Immunol., June 1, 2007; 14(6): 767 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. L. Thacker, D. J. Holtkamp, A. S. Khan, P. A. Brown, and R. Draghia-Akli Plasmid-mediated growth hormone-releasing hormone efficacy in reducing disease associated with Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus infection J Anim Sci, March 1, 2006; 84(3): 733 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Opriessnig, E. L. Thacker, S. Yu, M. Fenaux, X.-J. Meng, and P. G. Halbur Experimental Reproduction of Postweaning Multisystemic Wasting Syndrome in Pigs by Dual Infection with Mycoplasma hyopneumoniae and Porcine Circovirus Type 2 Vet. Pathol., November 1, 2004; 41(6): 624 - 640. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
