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Vet Pathol 40:507-511 (2003)
© 2003 American College of Veterinary Pathologists

Mitochondrial Myopathy in a German Shepherd Dog

O. Paciello, P. Maiolino, G. Fatone and S. Papparella

Dipartimento di Patologia e Sanità Animale–Settore Anatomia Patologica (OP, PM, SP) and Dipartimento di Scienze Cliniche Veterinarie–Sezione di Clinica Chirurgica (GF), Facoltà di Medicina Veterinaria, Università degli Studi di Napoli Federico II, Naples, Italy

A 9-month-old male German Shepherd dog was referred for evaluation of progressive exercise intolerance. Clinical examination revealed a stiff, stilted gait and marked atrophy and hypotonia of skeletal muscle. The dog had raised creatine kinase (181 U/liter), lactate dehydrogenase (510 U/liter), and aspartate aminotransferase (123.6 U/liter) levels, suggesting a muscle disease. Histochemical evaluation of muscle biopsies revealed the presence of subsarcolemmal oxidative activity, reduced nicotinamide adenine dinucleotide, and succinate dehydrogenase, and the absence of cytochrome oxidase activity. Ragged red fibers were demonstrated with Gomori trichrome stain. Ultrastructural examination of the muscle confirmed the presence of subsarcolemmal accumulations of mitochondria and morphologically atypical mitochondria.

Key words: Dogs; histochemistry; mitochondrial myopathy.

Request reprints from Dr. O. Paciello, Dipartimento di Patologia e Sanità Animale–Settore Anatomia Patologica, Facoltà di Medicina Veterinaria, Università degli Studi di Napoli Federico II, Via F. Delpino, 1,80137 Naples (Italy).




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