This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Costa, F. A. L. Articles by Guerra, J. L. Search for Related Content PubMed PubMed Citation Articles by Costa, F. A. L. Articles by Guerra, J. L. Social Bookmarking                            What's this?

Histopathologic Patterns of Nephropathy in Naturally Acquired Canine Visceral Leishmaniasis

Laboratório de Soroepidemiologia e Imunobiologia Celular e Molecular, Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, São Paulo, Brazil (FALC, HG); Departamento de Patologia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil (FALC, LCBS, ILS, TCS, JLG); and Departamento de Clínica e Cirurgia Veterinária, Centro de Ciências Agrárias, Universidade Federal do Piauí, Teresina, Piauí, Brazil (FALC, SMMSS)

Although the nephropathy of visceral leishmaniasis (VL) is known both in humans and dogs, histopathologic alterations have not been thoroughly studied. We examined renal alterations in 55 dogs with naturally acquired VL compared with five noninfected dogs from an endemic area in northeastern Brazil. Glomerulonephritis was found in 55 dogs, interstitial alterations in 53 dogs, and tubular changes in 43 dogs with VL. The glomerular alterations found were minor glomerular abnormalities (n = 8, 14.5%), focal segmental glomerulosclerosis (n = 10, 18.2%), mesangial proliferative glomerulonephritis (n = 17, 32.7%), membranoproliferative glomerulonephritis, (n = 18, 30.9%), crescentic glomerulonephritis (n = 1, 1.8%), and chronic glomerulonephritis (n = 1, 1.8%). Morphometric and ultrastructural studies complemented the analysis. The five control animals exhibited no glomerular alterations. The glomerular lesions were related to functional alterations. Considering that the alterations of canine and human nephropathy in VL are very similar, the data obtained in this study constitute an important contribution to the understanding of canine and human VL nephropathy.

Key words: Dogs; glomerulonephritis; morphometry; renal pathology; ultrastructure; visceral leishmaniasis.

Request reprints from Dr. H. Goto, Instituto de Medicina Tropical de São Paulo, Laboratório de Soroepidemiologia e Imunobiologia Celular e Molecular, 4° andar, Rua Dr. Enéas de Carvalho Aguiar, 470, CEP. 05403–000 São Paulo, SP (Brazil). E-mail: hgoto{at}usp.br.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				O. Cortadellas, M. J. F.-d. Palacio, J. Talavera, and A. Bayon Serum phosphorus concentrations in dogs with leishmaniosis at different stages of chronic kidney disease Vet Rec., April 18, 2009; 164(16): 487 - 490. [Abstract] [Full Text] [PDF]

				A. Beck, R. Beck, J. Kusak, A. Gudan, F. Martinkovic, B. Artukovic, M. Hohsteter, D. Huber, A. Marinculic, and Z. Grabarevic A Case of Visceral Leishmaniosis in a Gray Wolf (Canis lupus) from Croatia J. Wildl. Dis., April 1, 2008; 44(2): 451 - 456. [Abstract] [Full Text] [PDF]

				L. Aresu, F. Valenza, E. Ferroglio, P. Pregel, F. Uslenghi, A. Tarducci, and R. Zanatta Membranoproliferative glomerulonephritis type III in a simultaneous infection of Leishmania infantum and Dirofilaria immitis in a dog J Vet Diagn Invest, September 1, 2007; 19(5): 569 - 572. [Abstract] [Full Text] [PDF]