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Cervical and Vaginal Epithelial Neoplasms in Cynomolgus Monkeys

Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Winston-Salem, NC

Papillomavirus-associated cervical cancer is the second most common neoplasm in women but has rarely been reported in animals. This report describes cervical and vaginal intraepithelial neoplasms identified in routine histologic specimens obtained from 20 (5.2%) of 385 female cynomolgus macaques (Macaca fascicularis) being used in long-term studies. Lesion incidence was similar in both control and hormonally treated animals (4.7% and 5.5%, respectively). Neoplasms included benign vaginal papillomas, mild to severe intraepithelial dysplasias, and two invasive cervical carcinomas. Common morphologic features included koilocytosis, nuclear atypia, and expansion of the basal epithelium. Selective staining of lesions with at least one of three papillomavirus antibodies was observed in all cases (20 of 20). In contrast, immunostaining of lesions was negative for Epstein-Barr–related virus proteins (0 of 20). The unique similarities between the observed lesions and those seen in women suggest that macaques may provide a suitable animal model for study of papillomavirus oncogenesis.

Key words: Cervical intraepithelial neoplasia; immunohistochemistry; Macaca fascicularis; nonhuman primates; papillomavirus.

Request reprints from Dr. C. E. Wood, Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157-1040 (USA). E-mail: chwood{at}wfubmc.edu.

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				C. E. Wood, Z. Chen, J. M. Cline, B. E. Miller, and R. D. Burk Characterization and Experimental Transmission of an Oncogenic Papillomavirus in Female Macaques J. Virol., June 15, 2007; 81(12): 6339 - 6345. [Abstract] [Full Text] [PDF]