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Vet Pathol 41:446-449 (2004)
© 2004 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Transcription Factor GATA-4 Is a Marker of Anaplasia in Adrenocortical Neoplasms of the Domestic Ferret (Mustela putorius furo)

R. A. Peterson, II, M. Kiupel, M. Bielinska, S. Kiiveri, M. Heikinheimo, C. C. Capen and D. B. Wilson

Abstract

Adrenocortical neoplasms are a common cause of morbidity in neutered ferrets. Recently we showed that gonadectomized DBA/2J mice develop adrenocortical tumors that express transcription factor GATA-4. Therefore, we screened archival specimens of adrenocortical neoplasms from neutered ferrets to determine whether GATA-4 could be used as a tumor marker in this species. Nuclear immunoreactivity for GATA-4 was evident in 19/22 (86%) of ferret adrenocortical carcinomas and was prominent in areas exhibiting myxoid differentiation. Normal adrenocortical cells lacked GATA-4 expression. Two other markers of adrenocortical tumors in gonadectomized mice, inhibin-{alpha} and luteinizing hormone receptor, were coexpressed with GATA-4 in some of the ferret tumors. No GATA-4 expression was observed in three cases of nodular hyperplasia, but patches of anaplastic cells expressing GATA-4 were evident in 7/14 (50%) of tumors classified as adenomas. We conclude that GATA-4 can function as a marker of anaplasia in ferret adrenocortical tumors.

Key words: Adrenal cortex neoplasms; ferrets; luteinizing hormone receptors; Mustelidae; ovariectomy; orchiectomy; transcription factor.

Request reprints from Dr. D. B. Wilson, Department of Pediatrics, Box 8208, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110 (USA). E-mail: wilson_d{at}pcfnotes1.wustl.edu




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