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Vet Pathol 41:498-505 (2004)
© 2004 American College of Veterinary Pathologists

Kinetics of Infection and Effects on the Placenta of Clamydophila abortus in Experimentally Infected Pregnant Ewes

J. A. Navarro, J. N. García de la Fuente, J. Sánchez, C. M. Martínez, A. J. Buendía, C. B. Gutiérrez-Martín, E. F. Rodriguez-Ferri, N. Ortega and J. Salinas

Departmento de Anatomía y Anatomía Patológica Comparadas (JAN, JS, CMM, AJB) and Departmento de Sanidad Animal (NO, JS), Facultad de Veterinaria, Universidad de Murcia, Murcia, Spain; and Departmento de Patología Animal, Facultad de Veterinaria, Universidad de León, Leon, Spain (JNGF, CBG, EFR)

A Chlamydophila abortus–induced abortion model was carried out on the basis of the experimental infection of ewes at day 75 of gestation. The infection induced abortions and the birth of weak lambs during the last 3 weeks of pregnancy. To study the kinetics of the infection in the placenta and in other organs, infected ewes were killed at 105, 120, and 130 days of gestation and also several days after abortion or parturition. Infected ewes developed a systemic infection that caused a mild and transient pneumonia and focal hepatitis. Pathologic changes were observed in placentas at 120 day of gestation, although the lesions varied between animals and even between placentomes of the same placenta. The first placental area infected was the maternal stroma and epithelium next to the intercaruncular areas, where neutrophilic response seemed to control the infection. A substantial degree of multiplication of C. abortus was then observed in the trophoblast cells of the placentome, periplacentomal choriallantoic membranes, and hilius, with an inflammatory exudate composed mainly of neutrophils, some macrophages, and very scarce lymphocytes. After abortion, the lesions affected the intercotyledonary areas of the aborted placentas, whereas in the uterus significant lymphocyte infiltration was observed, together with a rapid decrease of the C. abortus antigen in the degenerated caruncular tissues.

Key words: Chlamydophila abortus; immunohistochemistry; ovine enzootic abortion; placenta; sheep.

Request reprints from Dr. J. A. Navarro, Departmento de Anatomía y Anatomía Patológica Comparadas, Facultad deVeterinaria, Universidad de Murcia, 30100 Murcia (Spain). E-mail: jnavarro{at}um.es




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N. Ortega, J. A. Navarro, L. Nicolas, A. J. Buendia, M. R. Caro, L. Del Rio, C. M. Martinez, F. Cuello, J. Salinas, and M. C. Gallego
Evaluation of Chlamydophila abortus DNA extraction protocols for polymerase chain reaction diagnosis in paraffin-embedded tissues
J Vet Diagn Invest, July 1, 2007; 19(4): 421 - 425.
[Abstract] [Full Text] [PDF]


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