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Vet Pathol 41:506-510 (2004)
© 2004 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Disseminated Infection with Balamuthia mandrillaris in a Dog

O. Foreman, J. Sykes, L. Ball, N. Yang and H. De Cock

Abstract

Bilateral chronic granulomatous nephritis and meningoencephalitis were diagnosed on necropsy of a 2-year-old male Great Dane dog. The causative agent was identified as Balamuthia mandrillaris, based on morphologic features, immunohistochemical staining, and deoxyribonucleic acid detection using the polymerase chain reaction with newly designed primer pairs. Trophozoite and cystic forms of the amoeba were evident within the kidneys and brain parenchyma. This is the first report on a B. mandrillaris infection in a dog.

Key words: Balamuthia mandrillaris; brain; canine; immunohistochemistry; kidney; polymerase chain reaction.

Request reprints from Dr. O. Foreman, Veterinary Medical Teaching Hospital, University of California, One Shields Avenue, Davis, CA 95616-8747 (USA). E-mail: oded{at}vmth.ucdavis.edu




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