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Vet Pathol 41:510-514 (2004)
© 2004 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Intracranial Fusariosis: A Novel Cause of Fungal Meningoencephalitis in a Dog

J. Evans, D. Levesque, A. de Lahunta and H. E. Jensen

Abstract

The Fusarium species are a group of saprophytic fungal organisms that are occasionally the cause of opportunistic infections in humans and animals. Central nervous system disease associated with a Fusarium species is most commonly described in horse, resulting in equine leukoencephalomalacia. This report describes a 2-year-old, spayed, female German Shepherd Dog with meningoencephalitis secondary to infection with Fusarium spp. Meningoencephalitis in dogs secondary to a species of Fusarium has not been previously reported. The diagnosis was made based on the histopathologic examination of brain tissues postmortem and special immunohistochemical stains specific for Fusarium solani. The clinical signs in this dog were indicative of multifocal brain disease and included seizures and a paradoxical vestibular syndrome. The clinical findings, diagnostic and histopathologic test results, and the comparative characterizations of other disseminated fungal diseases, especially aspergillosis, are described.

Key words: Aspergillosis; dogs; immunohistochemisry; meningoencephalitis; mycosis; paradoxical vestibular syndrome.

Request reprints from Dr. J. Evans, Veterinary Neurological Center, 4445 North Rainbow Boulevard, Las Vegas, NV 89108 (USA). E-mail: evans{at}vetneuro.com




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M. Nucci and E. Anaissie
Fusarium Infections in Immunocompromised Patients
Clin. Microbiol. Rev., October 1, 2007; 20(4): 695 - 704.
[Abstract] [Full Text] [PDF]


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