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Vet Pathol 41:702-707 (2004)
© 2004 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Extensive Lesions of Monkeypox in a Prairie Dog (Cynomys sp)

I. M. Langohr, G. W. Stevenson, H. L. Thacker and R. L. Regnery

Abstract

Monkeypox with extensive lesions was diagnosed in a prairie dog that was involved in a recent human outbreak of monkeypox in the Midwestern United States. Gross lesions included oral ulcers, pulmonary consolidation, enlarged cervical and thoracic lymph nodes, and multifocal, small, white umbilicated plaques in the gastrointestinal wall. Microscopic lesions were extensive in the lungs and consisted of fibrinonecrotic bronchopneumonia with vasculitis and poorly defined eosinophilic intracytoplasmic inclusion bodies in cells thought to be alveolar epithelial cells, histiocytes, and fibroblasts. Multifocal necrotizing lesions, often accompanied by myxedema, were also present in most of the other examined organs. Aggregates of pox viral particles were observed within lesions by transmission electron microscopy. Monkeypox virus infection was confirmed by real-time polymerase chain reaction and virus culture at the Centers for Disease Control and Prevention. This report highlights the difficulties of rapid diagnosis of exotic or emerging diseases and further substantiates the prairie dog as an animal model of monkeypox.

Key words: Monkeypox virus; pathology; prairie dogs (Cynomys sp.); ultrastructure.

Request reprints from Dr. Ingeborg M. Langohr, Animal Disease Diagnostic Laboratory, Purdue University, 406 South University, West Lafayette, IN 47907 (USA). E-mail: ilangohr{at}purdue.edu




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[Abstract] [Full Text] [PDF]


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