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Vet Pathol 42:100-103 (2005)
© 2005 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Estrogen-dependent Induction of Cyclooxygenase-2 in the Canine Prostate In Vivo

M. Doré, S. Chevalier and J. Sirois

Abstract

Cyclooxygenase (COX)-2 is involved in several physiologic and pathologic processes. COX-2 is overexpressed in human and canine prostate cancer, but little is known about COX-2 inducers in the prostate. Our objective was to investigate the effect of sex steroid hormones on COX-2 expression in the canine prostate in vivo. COX-2 expression was evaluated by immunohistochemistry in intact and castrated dogs treated with exogenous androgen or estrogen. Results showed that no COX-2 staining was observed in prostates of untreated or androgen-treated castrated or intact dogs. However, treatment of intact and castrated dogs with estrogen resulted in squamous metaplasia with intense COX-2 expression observed in both squamous epithelial cells and in cells of acini without metaplasia. This is the first report to demonstrate the induction of COX-2 by estrogen in the prostate in vivo.

Key words: Cyclooxygenase-2; dogs; estrogen; metaplasia; prostate.

Request reprints from Dr. M. Doré, Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, St-Hyacinthe, Québec, J2S 7C6 (Canada). E-mail: monique.dore{at}umontreal.ca




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