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Vet Pathol 43:67-75 (2006)
© 2006 American College of Veterinary Pathologists
BRIEF COMMUNICATIONS AND CASE REPORTS

Immunohistochemical Evaluation of Inflammatory Infiltrate in the Skin and Lung of Lambs Naturally Infected with Sheeppox Virus

M. Y. Gulbahar, W. C. Davis, H. Yuksel and M. Cabalar

Abstract

The present study describes immunophenotypic characteristics of inflammatory infiltrate in the skin and lung of lambs naturally infected with sheeppox virus (SPV). Three lambs revealed typical cutaneous and pulmonary lesions of sheeppox. Histologically, cutaneous and pulmonary lesions consisted of hyperplastic and/or degenerative changes in the epithelium with mononuclear cells, neutrophils, and typical sheeppox cells (SPCs), which had a vacuolated nucleus and marginated chromatin with occasional granular intracytoplasmic inclusions. The inflammatory infiltrate in pox lesions in both skin and lung was characterized by the presence of MHC II+ dendritic cells, CD4+, CD8+, {gamma}{delta}+ T cells, IgM+ cells, and CD21+ cells. Loss of expression of MHC I and MHC II antigens was observed in the affected areas of skin and lung. SPCs, stained with anti-SPV antibody, were also positive for CD14 and CD172A, antigens expressed on monocytes and macrophages. CD14 and CD172A negative SPCs were considered to be SPV infected degenerated epithelial cells or fibroblasts.

Key words: Immunohistochemistry; inflammatory infiltrate; lamb; lung; pox; sheeppox cells; sheeppox virus; skin.

Request reprints from Dr M Yavuz Gulbahar, University of Ondokuz Mayis, Faculty of Veterinary Medicine, Department of Pathology, Kurupelit, 55200 Samsun (Turkey). E-mail: mygulbahar{at}hotmail.com or myg64{at}omu.edu.tr




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M. Y. Gulbahar, W. C. Davis, T. Guvenc, M. Yarim, U. Parlak, and Y. B. Kabak
Myocarditis Associated with Foot-and-Mouth Disease Virus Type O in Lambs
Vet. Pathol., September 1, 2007; 44(5): 589 - 599.
[Abstract] [Full Text] [PDF]


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